YES! This happened to me too! I thought I was the only one. I don't even remember when I started taking alli, but I gained 4 lbs the first week, lost 2, gained 2, etc. I saw my doctor and she prescribed Meridia to take with the alli, which was supposed to help supress my appetite. I didn't lose much weight with that either, and started feeling very agitated and irritable. When i found out Meridia had the same mechanism as antidepressants, I was furious that I'd spent $140 on it. I'd been taking antidepressants since I was 15, and they only ever CAUSED weight gain. When I became pregnant nearly 2 years ago, I stopped taking antidepressants for the first time in 10 years, and I saw a DRAMATIC change in my mood swings and depression... they all but disappeared. I had been periodically hospitalized a couple of times a year for severe depressive episodes, but since I've quit the psyc meds, nothing! And about 2-3 weeks after I started the meridia, I began experiecing mood changes that my family started to see.
I eventually started forgetting to take pills after the first month because I saw no progress at all and was discouraged. It also started seeming like my tolerance for fat in terms of TE's with alli was getting smaller and smaller. I didn't have ANY TE's at all for the first month or so, and then started having them with 15 grams of fat meals. I woke up one morning to take a shower, and realized that I had leaked oiled during the night.... I believe that's when I quit. I haven't taken a pill for 2 weeks, and suddenly, I'm losing weight now! I've lost 6 pounds in the last week alone. At one point on alli, I had gotten up to 186, but now I'm 173 today. In the three weeks since I stopped alli/meridia, I've lost 13 pounds. How is that possible? Even though I dumped the pills, I did continue a low fat/low calorie plan. A year ago, I was nearly 9 months pregnant and 150 lbs, and the 10 years before that I was 120 (despite what I ate). I'm 26 and 5'9".
Started alli - 4/8/08
Stopped alli - 5/16/08
5 feet; 8.5 inches, small frame
SW: 180.8
SW +1 week on alli: 186.0
CW: 171
GW: 130
26/F/Georgia
New mommy to a beautiful baby Riley (10 mo.)