First of all, I have to say that I believe Alli really works. (Or at least it has for me.) I was skeptical because I saw no treatment effects of any kind but managed to lose 7 pounds in 2 weeks - I was monitoring what I ate very closely - I did have a hard time eating enough calories & fat most of those two weeks. But, the whole time I was on Alli (2 weeks), I was severely depressed. I've never been like that in my entire life. I know that Alli is supposed to work only in your gut and have no effect whatsoever on your central nervous system, but I know that it did cause my depression. I cried off & on the whole time and did not want to do ANYTHING. I could have spent the rest of my life curled up in my recliner (which is totally not like me). Finally, last Thursday, my close friend asked me to stop taking the Alli for a few days just to see if I felt better - and I do. I'm my old self again. I haven't changed my diet ONE BIT. I'm eating EXACTLY what I did during the two weeks I was on Alli. I know that the experts are going to disagree with me, but I'm sure that Alli was the cause of my depression. I may wait a little while and try to take it again to see if it affects me the same way. I'm hoping it doesn't because I believe in Alli.