Hi Shyloxmom,
Alli is active for 2 hours, if you are to eat a meal that is over in the fat grams you simply need to skip the dose with the meal. Depending on how long you have been on the alli plan or following a low fat diet, you may find your taste for food has changed, and foods high in fat are not as desireable.
Hope this helps.
Sophia De Monte RPh